Estradiol is a female hormone (estrogen). It is used by women to help reduce vaginal symptoms of menopause. Learn about side effects, drug interactions, dosages, warnings, and more. Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body. It is available as an oral tablet, a topical gel or patch, vaginal cream, or as an injection. Estradiol tablet is an estrogen hormone used to treat menopause symptoms like hot flashes, night sweats, and vaginal irritation. It also helps prevent bone loss (osteoporosis) after menopause. Estradiol is a synthetic (man-made) form of estrogen hormone that works by replacing declining natural estrogen levels, particularly after menopause. Find patient medical information for Estradiol (Delestrogen, Depo-Estradiol, Estrace) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings ESTRADIOL (es tra DYE ole) reduces the number and severity of hot flashes due to menopause. It may also help relieve the symptoms of menopause, such as vaginal irritation, dryness, or pain during sex. Estradiol is an estrogen hormone. The hormone from the patch, gel, and spray is absorbed through your skin into your body. This medicine is available only with your doctor's prescription. Estradiol (E2), also called oestrogen, oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of female reproductive cycles such as estrous and menstrual cycles. Estradiol (E2) is the most potent and clinically measured form of estrogen. It is produced primarily in the ovaries in women, in small amounts by the testes in men, and in fat tissue in both sexes. Estradiol is a drug prescribed to treat the symptoms of menopause and prevent bone fractures (osteoporosis), painful uterine bleeding, vaginal pain, dryness, and atrophy associated with menopause. Estradiol is also prescribed for the treatment of breast cancer, and some cases of prostate cancer.